Fig. 2
From: Intrinsic disorder in PRAME and its role in uveal melanoma
Amino acid composition profile of PRAME. The fractional difference is calculated as \(\frac{{C}_{x- }{C}_{order}}{{C}_{order}}\), where Cx is the content of a given amino acid in the query set (PRAME), and Corder is the content of a given amino acid in the background set (Protein Databank Select 25). Amino acids marked with (*) are statistically significant for enrichment (L and S) or depletion (G and N) (p-value < 0.05). The amino acid residues are ranked from most order promoting residues ((i.e., cysteine (C), tryptophan (W), isoleucine (I), tyrosine (Y), phenylalanine (F), leucine (L), histidine (H), valine (V), asparagine (N), and methionine (M)) to most disorder promoting residues ((i.e., arginine (R), threonine (T), aspartate (D), glycine (G), alanine (A), lysine (K), glutamine (Q), serine (S), glutamate (E), and proline (P)). Positive values indicate enrichment, and negative values indicate depletion of amino acids