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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1

Fig. 6

ATRA and Sorafenib synergistically inhibited proliferation and anchorage-independent growth of HCC cells. A PLC and Huh7 cells were treated with ATRA (0, 40 μM) and Sorafenib (0, 2, 4, 8, 16 and 32 μM) for 48 h, and cell growth was determined by CCK-8 assay. The IC50 values were calculated and listed in (B). The coefficient of drug interaction (CDI) calculated using relative viability values for PLC (C) and Huh7 (D) cells showed the synergistic effect of ATRA and Sorafenib. ATRA and Sorafenib synergistically inhibited the colony formation of PLC (E) and Huh7 (F) cells. The data are from three independent experiments

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Cell Communication and Signaling

ISSN: 1478-811X