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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1

Fig. 2

Overexpression of PAK1 promoted proliferation, migration/invasion, and anchorage-independent growth of HCC cells. A The mRNA expression of PAK1 and protein levels of PAK1 and pPAK1 in Hep3B, PLC and Huh7 cells were measured by qRT-PCR and Western blotting, respectively. B The mRNA expression of PAK1 and protein levels of PAK1 and pPAK1 in a vector-only (VO) clone and a PAK1-overexpressing (OE) clone of Hep3B cells were determined by qRT-PCR and Western blotting. Cell viability (C), sphere formation (D), colony formation (E) and cell invasion (F) and migration (G) of VO and OE Hep3B cells were measured. n.s., not significant; **p < 0.01, ***p < 0.001, compared with Hep3B or VO. Scale bar, 100 μm. The data are from three independent experiments

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Cell Communication and Signaling

ISSN: 1478-811X