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Table 6 The biological characteristics of different tissue-derived mesenchymal stem cells

From: The role of MSCs and CAR-MSCs in cellular immunotherapy

 

Bone morrow

Adipose tissue

Perinatal tissues

hESC-derived

Accessibility

 + 

 + 

 +  + 

 +  + 

Pain

Yes

Yes

No

No

Ethical issues

Yes

Yes

No

No

morphology

Larger

Average

Smaller

Larger

Proliferation

 + 

 +  + 

 +  +  + 

 +  +  + 

Senescence

 +  +  + 

 +  + 

 + 

 + 

Adipocytes differentiation potential

 + 

 +  + 

 + 

 + 

Osteoblasts differentiation potential

 +  + 

 + 

 + 

 + 

Chondroblasts differentiation potential

 +  + 

 + 

 +  + 

 + 

Secretion of Soluble Factors

 + 

 + 

 +  + 

 + 

Secretion of EVs and miRs

 + 

 + 

 + 

 + 

Immunomodulation

 +  + 

 + 

 +  +  + 

 +  +  + 

  1. Notes: miRs Microribonucleic acids, EVs Extracellular vesicles. hESC Human embryonic stem cell