Skip to main content

Table 3 Compare of CAR-T cells and CAR-T cells derived EV

From: The role of MSCs and CAR-MSCs in cellular immunotherapy

 

CAR-T cells

CAR-T cell derived EV

Cytokine releasing syndrome

 +  + 

 − 

Neurotoxicity

 +  + 

 − 

Cross the blood barrier

 − 

 +  + 

Efficiency against solid tumors

 + / − 

 +  + 

Immunosuppression by tumoral PD-L1

 + 

 − 

Immunological memory

 + 1

(?)2

  1. Notes: CAR-T cells Chimeric antigen receptor T cells, EV Extracellular vesicles, PD-L1 programmed death-1 ligand,
  2. 1Depends on the use of central memory or effector memory CAR T cells
  3. 2Not formally established
Back to article page

Cell Communication and Signaling

ISSN: 1478-811X