Fig. 8
From: The role of MSCs and CAR-MSCs in cellular immunotherapy
Exosome structure and molecular composition. Exosomes are surrounded by a phospho-lipid bilayer and contain nucleic acids and lipids, proteins. Exosomal proteins include annexins, important for transport; integrins and tetraspanins important for cell targeting and binding, and TSG101and Alix, involved in exosomal biogenesis from endosomes. Notes: MHC: Major histocom-patibility complex; HSP: Heat shock protein; TSG101: Ttumor susceptibility gene 101; TCR: T cell receptor; BCR: B cell receptor; CD73: Cluster of differentiation 36; CD39: Cluster of differentiation 39; MMP9: Matrix metalloproteinase-9; MMP14: Matrix metalloproteinase-14; MFGE8: milk fat globuleEGF factorVIII; ICAM: Intercellular adhesion molecule; LFA-1: Lymphocyte function-associated antigen-1; VPS32: Vacuolar protein sorting-associated protein 32; FasL: Fas ligand; LBPA: Lysobisphosphatidic acid; ARFs: Auxin response factors; RABs: Rab family of proteins; ALIX: ALG-2 interacting protein X; mRNA: Messenger nucleic acid; miRNA: Microribonucleic acid