Fig. 10
From: The role of MSCs and CAR-MSCs in cellular immunotherapy
The structure and construction of CAR-T and the mechanism of anticancer. The T/NK cell can be engineered to express CAR with its binder from monoclonal antibodies. The CAR consist of the co-stimulatory domain and signalling domain (CD3zeta). A viral vector is used to transfer the DNA that codes for CAR into the nucleus of the immune cell. The signal is amplified and transferred to the nucleus after the CAR receptor recognizes the tumor antigen. Then, the T/NK cell may proliferate and secrete cytokines, perforins to initiate a series of antitumor responses. Notes: CAR: Chimeric antigen receptor; IL-2: Interleukin 2