Fig. 1
From: Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior
HCAR1 transcriptomic signature modulates wide range of pathologies. a Heatmap of HCAR1 RNA-seq in HeLa cell lines. KD and scrambled shRNA cells were treated with PBS or lactate and subjected to RNA-sequencing. b Number of DEGs through HCAR1 with and without lactate treatment. c Venn diagram showing the overlap of DEGs through HCAR1 with or without lactate. d Disease association with DEGs in HCAR1 PBS treated groups. HCAR1 + PBS down: downregulated genes upon HCAR1 KD in PBS treated cells. HCAR1 + PBS up: upregulated genes upon HCAR1 KD in PBS treated cells. e Disease association with DEGs in HCAR1 lactate treated groups. HCAR1 + Lact down: downregulated genes upon HCAR1 KD in PBS treated cells. HCAR1 + Lact up: upregulated genes upon HCAR1 KD in PBS treated cells. f Volcano plot for DEGs specific to HCAR1 + lact group (the 516 genes in c). g Clustergram showing DEGs associated with each term. DEG: differentially-expressed genes; KD: knockdown