Skip to main content
Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer

Fig. 7

Transcriptional diversity in fibroblast and endothelial cells. (A) UMAP of five fibroblast subclusters. Relative proportion of these clusters in four different treatments were showed on the right. IgG: immunoglobulin G isotype control; PD-1: PD-1 immune-checkpoint blockade antibody; SMI: SMI monotherapy; PD-1+SMI: combination of anti-PD-1 and SMI. (B) Dot plot showing expression of GFPT2, MMP14, MMP2, TGFB1, CCL5, CCL2, JUN, FOS, and FOSB in five fibroblast subclusters. (C) Dot plot showing the top representative biological pathways of five fibroblast subclusters based on DEGs using Metascape analysis. (D) High level of GFPT2 predicted poor prognosis in TCGA-LUSC.htseq_counts.tsv (n = 550 samples). Log-rank P < 0.05 was considered as statistically significant. (E) UMAP of six endothelial cell subclusters. Relative proportion of these clusters in four different treatments were showed on the right. (F) Dot plot showing expression of KDR and FLT1 in six endothelial cell subclusters. (G) Dot plot showing the top representative biological pathways of six endothelial cell subclusters based on DEGs using Metascape analysis. (H) Violin plot showing expression of EZH2, TCF12, S100A4, STMN1, TOP2A, THBS1, TIMP2, and MAF in six endothelial cell subclusters

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X