Fig. 2
From: Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Detachment of normal breast cells from their native environment triggers activation of adhesion mediators on the cell membrane, inhibition of survival pathways (e.g., PI3K-AKT, MEK-ERK), and simultaneous alteration of the cytoskeletal structure, triggering a BCL2 family protein response, activation of the mitochondrial pathway of apoptosis, and ultimately the release of caspases, triggering anpikis