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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Fig. 7

B56γ3 expression was upregulated in CRC and correlated with AKT activation and poor prognosis. A Representative micrographs of IHC analysis of B56γ3 and phosphorylation of AKT (p-AKT, Ser473) in tumor parts and normal tissue counterparts of 57 human colon cancer specimens are shown. Micrographs shown are four paired tissue specimens with higher IHC scores of both B56γ3 and p-AKT in tumor parts compared to that in normal tissue counterparts. Micrographs are shown at magnification 200X. The scale bar is 50–100 μm. B Scatter plots shown are quantitative analysis of scores of staining of expression of B56γ3 (Left) and p-AKT (Right) in both tumor and non-tumor parts of 57 paired human colon cancer specimens. C Data shown are concordance analysis of IHC scores of B56γ3 and p-AKT in tumor tissues. D Kaplan–Meier survival analysis of two cohorts (GSE16125 and GSE17537) of CRC patients with PPP2R5C (B56γ) high or PPP2R5C (B56γ) low expression. P values were calculated using two-tailed unpaired Student’s t-test with p value (* (< 0.05), ** (< 0.01), ***(< 0.001))

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Cell Communication and Signaling

ISSN: 1478-811X