Involvement of the SIRT1-NLRP3 pathway in the inflammatory response

Table 1 The anti-inflammatory pathways of the inflammatory response-related diseases

Organ	Diseases	Pathway of the inhibition	Ref
Brain	Traumatic brain injury Depression Neuroinflammation	SIRT1-NLRP3/ROS SIRT1-NLRP3/NF-κB SIRT1-NLRP3/Nrf2	[26,27,28] [29] [30]
Heart	Atherosclerosis	SIRT1-NLRP3/IL-1β	[31, 32]
Lung	Chronic obstructive pulmonary disease	SIRT1-NLRP3/IL-1β	[33]
Liver	Liver damage	SIRT1-NLRP3/Nrf2	[34,35,36]
Pancreas	Diabetes mellitus	SIRT1-NLRP3	[37]

SIRT1 Silent information regulator 2 homolog 1, NLRP3, NACHT LRR and PYD domains-containing protein 3, ROS Reactive oxygen species, NF-κB Nuclear factor-kappa B, Nrf2 Nuclear factor erythroid 2-related factor 2, IL-1β Interleukin (IL)-1β

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