Fig. 3
From: Involvement of the SIRT1-NLRP3 pathway in the inflammatory response
Melatonin in airway inflammation. Melatonin exerted a protective effect which was further suggested to be dependent on targeting its membrane receptor (MT) 1 or 2 against airway inflammation in COPD. This is attributed to the inhibition of NLRP3 inflammasome and IL-1β via the activation of SIRT1 in the lung tissues of whom with COPD. (Sirt1: Silent information regulator 2 homolog 1; NLRP3: NACHT, LRR and PYD domains-containing protein 3; ASC: a protein; IL: Interleukin; MT: Membrane receptor)