Fig. 1
From: Involvement of the SIRT1-NLRP3 pathway in the inflammatory response
The structure of NLRP3 inflammasome. NLRP3 is a tripartite protein that contains an aminoterminal pyrin domain (PYD), a central NACHT domain, and a carboxy-terminal leucine-rich repeat (LRR) domain. NLRP3 recruits ASCs through PYD-PYD interactions. In turn, pro-caspase-1 is recruited by ASC through CARD-CARD interactions to form the NLRP3-ASC-pro-caspase-1 inflammasome. (NLRP3: NACHT, LRR and PYD domains-containing protein 3; PYD: Pyrin domain; NACHT: Domain present in NAIP, CIITA, HETE and TP1; LRR: Leucine-rich repeat; ASC: a protein; CARD: C-terminal caspase-recruitment domain; ATP: Adenosine triphosphate; ADP: Adenosine diphosphate)