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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: P38-DAPK1 axis regulated LC3-associated phagocytosis (LAP) of microglia in an in vitro subarachnoid hemorrhage model

Fig. 4

Improved LAP induced by P38 inhibitor. The protein expression of LC3 II after PD98059, JNK-IN-8 and SB203580 added (a). The change of microglial phagocytosis after PD98059, JNK-IN-8 and SB203580 added (b). Immunofluorescence analysis of pHrodo and LC3 (c) showing the number of particles (d) and LC3 + particles (e) after SB203580 added. Protein bands (f) and semi-quantitative analysis (g) showing the protein expression of BECN1 and RUBICON after SB203580 (SB) added. The mRNA expression of Il-1β, Il-6 and Nlrp3 after SB203580 (SB) added (h). ****-P < 0.0001, ***-P < 0.001, **-P < 0.01, *-P < 0.05; ns, non-significant. Scale bar: 3 μm

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Cell Communication and Signaling

ISSN: 1478-811X