Table 4 Either Ala and PD123319 could improve Ang II-induced cardiac dysfunction in the rat

LVEF (%)

77.55 ± 0.9196

78.95 ± 2.161

76.16 ± 1.916 ^ns

78.21 ± 0.9513 ^ns

79.96 ± 1.846 ^ns

LVFS (%)

47.99 ± 0.8531

49.31 ± 2.203

46.70 ± 1.775 ^ns

48.54 ± 0.9681 ^ns

50.36 ± 1.881 ^ns

LV mass (mg)

1156 ± 44.45

1423 ± 53.10

1194 ± 54.51 ^*

1190 ± 49.12 ^*

1119 ± 52.87 ^*

LVIDs (mm)

4.310 ± 0.1485

3.676 ± 0.1819

4.241 ± 0.2022

4.091 ± 0.1202

3.731 ± 0.1895 ^ns

LVIDd (mm)

8.278 ± 0.1828

7.255 ± 0.2117

7.935 ± 0.1295 ^ns

7.951 ± 0.1818 ^ns

7.511 ± 0.2318 ^ns

LVAW;s (mm)

2.834 ± 0.0642

3.762 ± 0.0573

2.898 ± 0.1117 ^****

3.359 ± 0.0419 ^**

3.033 ± 0.0634 ^****

LVAW;d (mm)

1.764 ± 0.04898

2.410 ± 0.07515

1.872 ± 0.03872 ^****

1.889 ± 0.02203 ^****

1.852 ± 0.05904 ^****

LVPW;s (mm)

2.827 ± 0.08314

3.571 ± 0.09882

3.255 ± 0.03894 ^ns

3.374 ± 0.04458 ^ns

3.296 ± 0.1012 ^ns

LVPW;d (mm)

1.809 ± 0.06843

2.347 ± 0.1110

1.959 ± 1.05446 ^**

1.930 ± 0.06183 ^**

2.001 ± 0.04534 ^*

Heart weight (mg)

1156 ± 40.08

1647 ± 34.69

1222 ± 56.30 ^****

1261 ± 17.10 ^****

1200 ± 19.76 ^****

Body weight (g)

386.3 ± 15.971

358.6 ± 10.37

386.9 ± 14.34 ^ns

402.3 ± 17.10 ^ns

373.0 ± 10.44 ^ns

Tibia length (mm)

48.06 ± 0.2562

48.07 ± 0.2337

47.87 ± 0.2186 ^ns

47.87 ± 0.2186 ^ns

47.78 ± 0.1833 ^ns