Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling

Table 3 PTX pre-treatment blocked the cardioprotective effects of silencing MrgD on Ang II-induced cardiac dysfunction in the rat

Variables	PBS (n = 6)	Ang II (n = 6)	Ang II + MrgD shRNA (n = 6)	Ang II + MrgD shRNA + PTX (n = 6)
LVEF (%)	76.87 ± 1.034	78.14 ± 1.546^ns	79.88 ± 1.113	75.85 ± 1.678^ns
LVFS (%)	47.30 ± 0.9982	48.34 ± 1.508^ns	50.15 ± 1.070	46.09 ± 1.567^ns
LV mass (mg)	1137 ± 42.25	1630 ± 108.1 ^***	1279 ± 58.35	1526 ± 56.63^ns
LVIDs (mm)	4.291 ± 0.1270	3.793 ± 0.1080 ^*	3.891 ± 0.1251	3.828 ± 0.0694^ns
LVIDd (mm)	8.144 ± 0.2041	7.346 ± 0.0865 ^**	7.753 ± 0.0786	7.333 ± 0.1876^ns
LVAW;s (mm)	2.858 ± 0.05936	4.101 ± 0.2250 ^****	3.131 ± 0.06436	3.670 ± 0.1059 ^#
LVAW;d (mm)	1.786 ± 0.04700	2.573 ± 0.1292 ^****	2.123 ± 0.06021	2.427 ± 0.06379 ^#
LVPW;s (mm)	2.813 ± 0.07173	3.749 ± 0.1851 ^****	2.822 ± 0.1032	3.440 ± 0.07458 ^##
LVPW;d (mm)	1.812 ± 0.05791	2.567 ± 0.1251 ^****	2.143 ± 0.08041	2.497 ± 0.04042 ^#
Heart weight (mg)	1196 ± 41.28	1576 ± 47.00 ^***	1315 ± 76.10	1575 ± 36.22 ^#
Body weight (g)	360.0 ± 5.971	349.3 ± 14.03^ns	346.7 ± 8.065	360.0 ± 10.41^ns
Tibia length (mm)	48.06 ± 0.2562	48.07 ± 0.2337^ns	47.87 ± 0.2186	47.78 ± 0.1833^ns

Echocardiographic data of mice from different groups. The results are expressed as the mean ± SEM (LVEF Left ventricular ejection fraction, LVFS Left ventricular fractional shortening, LVIDs LV internal diameters at end systole, LVIDd LV internal diameters at end diastole, Volume;s Volume at end systole, Volume;d Volume at end diastole, LVAW;s Left ventricular systolic anterior wall, LVAW;d Left ventricular diastolic anterior wall, LVPW;s Left ventricular systolic posterior wall, LVPW;d Left ventricular diastolic posterior wall). (^*: vers PBS group; ^#: vers Ang II + MrgD shRNA group)
^nsP > 0.05, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001; ^#P < 0.05, ^##P < 0.01

ISSN: 1478-811X