Skip to main content
Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling

Fig. 4

Effects of Ala or PD123319 on Ang II-induced cardiac remodeling. A, HW/BW and HW/TL were decreased after Ala or PD12339 pretreatment in the heart compared with those in the Ang II group. B, the mRNA levels of Nppa and Nppb, as well as the ratio of Myh 6/7 in the hearts from different groups. C, Ala or PD12339 pretreatment decreased the cardiac fibrosis level in the Ang II-induced rats, as indicated by masson and picrosirius red staining. D-E, the protein and mRNA levels of α-SMA, TGF-β and collagen I in the hearts from different groups. The results are expressed as mean ± SEM. n = 3 biological replicates per group. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X