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Fig.8 | Cell Communication and Signaling

Fig.8

From: Myofiber directs macrophages IL-10-Vav1-Rac1 efferocytosis pathway in inflamed muscle following CTX myoinjury by activating the intrinsic TGF-β signaling

Fig.8

Myofiber TGF-β-IL-10 signaling effects on macrophage phenotype and efferocytosis related-molecules expression. FACS analysis of Bcl3, p-STAT3, Vav1, GTPase Rac1, CD206 and CX3CR1 in macrophages co-cultured with TGF-βr2.−/−- or control-MPC-Myotubes, exposed to pro-inflammatory milieu, and treated with or without SRI, rmIL-10 or AS101, respectively. Multiple comparisons were analyzed by One-way ANOVA. Statistical data were expressed as mean ± SD (n = 3). (*P < 0.05, **P < 0.01)

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Cell Communication and Signaling

ISSN: 1478-811X