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Fig.6 | Cell Communication and Signaling

Fig.6

From: Myofiber directs macrophages IL-10-Vav1-Rac1 efferocytosis pathway in inflamed muscle following CTX myoinjury by activating the intrinsic TGF-β signaling

Fig.6

Endogenous TGF-β signaling regulates IL-10 production in regenerating myofiber. Transcriptome assay (A), qRT-PCR analysis (B) and Luminex analysis (C) of gene levels of some myokines, mRNA level of IL-10, protein levels of some myokines in TGF-βr2−/−- or control-MPC-Myotubes exposed to pro-inflammatory milieu, respectively. qRT-PCR analysis (D) of IL-10 mRNA level in inflamed muscle. Immunofluorescence staining (E) showed IL-10 expression change in regenerating myofibers. Multiple comparisons were analyzed by One-way ANOVA. Statistical data were expressed as mean ± SD (n = 3). (*P < 0.05, **P < 0.01). Bar = 50 μm

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Cell Communication and Signaling

ISSN: 1478-811X