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Fig.4 | Cell Communication and Signaling

Fig.4

From: Myofiber directs macrophages IL-10-Vav1-Rac1 efferocytosis pathway in inflamed muscle following CTX myoinjury by activating the intrinsic TGF-β signaling

Fig.4

Myofiber drives macrophages efferocytosis by priming intrinsic TGF-β signaling. A, Immunofluorescence shows UV-inducted mononuclear cells apoptosis and PKH67 labeling. B, FACS analysis of the percent of M2 macrophages (F4/80+CD206+ or F4/80+CX3CR1+) sorted from inflamed muscle injected with exogenous ACs or not. C, Immunofluorescence shows the uptake of PKH67+ apoptotic cells in macrophages after exogenous apoptotic cells transferring into inflamed muscle. D, FACS analysis of the percent of efferocytosis macrophages (F4/80+PKH67+) sorted from inflamed muscle injected with exogenous ACs or not. LCs: Living cells; ACs: Apoptotic cells; Multiple comparisons were analyzed by One-way ANOVA. Statistical data were expressed as mean ± SD (n = 3). (*P < 0.05, **P < 0.01). Bar = 50 μm

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Cell Communication and Signaling

ISSN: 1478-811X