Table 1 Genetic inhibition for blocking mito-nuclear communication in CSCs
From: Cancer stem cell fate determination: mito-nuclear communication
Patterns of mito-nuclear communication | Names of genes | Mechanisms of action | CSC types and tissue origins |
|---|---|---|---|
Mitochondrial fission | DRP1 | Reduces the capability of tumorsphere and tumor formation, especially the self-renewal of CSCs | CD133+CD15+ BTICs [92] |
MFF or BRD4 | Reduces the capability of tumorsphere and tumor formation, especially the self-renewal of CSCs | Prostate CSCs [112] | |
FIS1 | Reduces the expression levels of stemness genes and inhibits tumorsphere and tumor formation, especially the self-renewal of CSCs | sphere enriched Lung CSCs [113] | |
Mitophagy | PINK1 and TBC1D15 | Decreases the levels of self-renewal markers | LSCs [103] |
ATG14 | Decreases the expression levels of self-renewal and stemness markers and the number of tumorspheres | CSCs in oral squamous cell carcinoma [114] | |
BNIP3L | Decreases the expression levels of stemness markers and the percentage of SP+ subpopulations | LCSCs [115] |