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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma

Fig. 9

Working model of METTL3-STAT3 positive feedback loop in promoting HCC metastasis. METTL3 induces m6A modification to enhance STAT3 translation. Upregulated STAT3 interacts with WTAP promoter and stimulates the transcription of WTAP. Elevated WTAP promotes the nuclear localization of METTL3, facilitating m6A modification of target genes, including STAT3. Finally, they form a positive feedback loop to constantly enhance the expression of STAT3, thereby facilitating cell metastasis in HCC

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Cell Communication and Signaling

ISSN: 1478-811X