Fig. 7
METTL3-STAT3 positive feedback loop promotes cell metastasis in vitro. A Western blotting analysis of METTL3 and STAT3 in the indicated cells shows the corresponding interfere/overexpress efficiency. The right panel shows the quantification of intensity relative to tubulin. Error bars represent mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed Student’s t-test. B, C Wound healing assay of the migration ability in the indicated cells. D-F Transwell assay of the migration and invasion abilities in the indicated cells. G Wound healing assay of the migration ability in HCCLM3 cells transfected with indicated siRNAs and plasmids. H-J Transwell assay of the migration and invasion abilities in HCCLM3 cells transfected with indicated siRNAs and plasmids. Error bars represent mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA