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Table 1 Kinetic parameters of the interaction between the studied galectins and FGF4

From: Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

 

KD1 [M]

KD2 [M]

Kon1[M− 1 s− 1]

Kon2[M− 1 s− 1]

KOff1 [s− 1]

KOff2 [s− 1]

gal-1

9.1E-07a

     

gal-3

1.42E-07

1.07E-06

1.39E + 03

5.02E + 05

1.97E-04

5.38E-01

gal-7

2.68E-07

4.97 E-07

1.21 E + 03

1.20E + 05

3.23E-04

5.96E-02

gal-8

7.24E-07

1.40E-07

1.04E + 05

8.23E + 02

7.55E-02

1.15E-04

  1. afor the interaction of galectin-1 with FGF4, as experimental data did not fit the kinetic models, steady-state analysis was used to determine Kd. Two values of KD, kon and koff were obtained from a 2:1 heterogenous ligand model, which was used to fit experimental kinetics data fitting
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Cell Communication and Signaling

ISSN: 1478-811X