Physiological and pathological consequences of exosomes at the blood–brain-barrier interface

Salimi, Leila; Seyedaghamiri, Fatemehsadat; Karimipour, Mohammad; Mobarak, Halimeh; Mardi, Narges; Taghavi, Maryam; Rahbarghazi, Reza

doi:10.1186/s12964-023-01142-z

Cell Communication and Signaling

Table 2 The role of Exo in the diagnosis, therapy, and function in angiogenesis

From: Physiological and pathological consequences of exosomes at the blood–brain-barrier interface

Exosomal cargo	Mechanisms	Target cell	Function	References
Annexin A2	Making of plasmin	Macrophages and ECs	Pro-angiogenesis	[115]
Angiopoietin-2	Tie2-unrelated route	HUVECs	Pro-angiogenesis	[116]
Alcohol acetyltransferase II, Metastasis Associated 1, Seryl-TRNA Synthetase 1, Rho-associated coiled-coil containing protein kinase 1/2	Increased VEGF and HIF-1 expression	HUVECs	Pro-angiogenesis	[117]
Carbonic anhydrase 9	Enhancing the transcription of MMP-2	HUVECs	Pro-angiogenesis	[118]
SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase, insulin-like growth factor 1 receptor, Focal adhesion kinase	VEGF overexpression	Endothelial cells	Pro-angiogenesis	[119]
The cluster of differentiation 147	increase in VEGF and MMP	HUVECs	Pro-angiogenesis	[120]
Delta Like Canonical Notch Ligand 4	Stopping notch indication	U373 and HUVECs	Pro-angiogenesis	[121]
EGF Like Repeats And Discoidin Domains 3	encourage cell migration and expansion		Pro-angiogenesis	[122]
Epidermal growth factor receptor III	By initiating the MAPK and Akt paths, the interpretation of the VEGF gene is increased	U373 and HUVECs	Pro-angiogenesis	[123]
Family With Sequence Similarity 225 Member A lncRNA	By disappointing its receptors NETO2 and FOXP1 as a result of miR-206 mooching, the PI3K/Akt/NF-B/Snail axis is activated	HUVECs	Pro-angiogenesis	[124]
High Mobility Group Box 3	In vivo and in vitro, nEXOs that included HMGB3 sped up vasculature	HUVECs	Pro-angiogenesis	[125]
Influence of interleukin-8	Regulation via MAPK	HUVECs	Pro-angiogenesis	[126]
Intercellular Adhesion Molecule 1, CD44v5	p38 MAPK, RhoA/ROCK, ERK1/2 kinase, Src kinase, and eNOS	HUVECs	Pro-angiogenesis	[127]
lncRNA UCA1	The mechanism for AMOTL2/ERK1/2 Trafficking	HUVECs	Pro-angiogenesis	[128]
IL-6, VEGF, and MMP-2	Route for WNT5A signal	Endothelial cells	Pro-angiogenesis	[129]
IL-8, PDGF	PI3K/AKT Trafficking	Endothelial cells	Pro-angiogenesis	[130]
GM-CSF, HIF1α, HIF-2α	Increased VEGF transcription	ECs and M1/M2 macrophages	Pro-angiogenesis	[131]
miR-148a-3p	Constraining ERRFI1 to activate the EGFR/MAPK transcription factors	HUVECs	Pro-angiogenesis	[132]
miR-373	β-catenin/ Wnt Trafficking	Endothelial cells	Pro-angiogenesis	[133]
miR-155	VEGF-A expression is increased through the VHL/HIF-1 route	ARPE-19	Pro-angiogenesis	[134]
miR-182-5p	concentrating on Elements 2 and 4 as Kruppel	HUVECs	Pro-angiogenesis	[135]
miR-9	JAK-STAT mechanism	Endothelial cells	Pro-angiogenesis	[136]
miR-497	VEGF and HIF-1 production are both downregulated	HUVECs	Anti-angiogenesis	[137]
miR-135b	Elimination of FIH-1	Endothelial cells	Pro-angiogenesis	[138]
miR-141	miR-141/KLF12 passageway in Exos	HUVECs	Pro-angiogenesis	[139]
miR-10b	reduction in the amount of HOXD10 and KLF4 proteins	HUVECs	Promotes cell invasion	[140]
miR-145	STIM1 stimulates vasculature by inhibiting the IRS1-targeting exosomal miR-145	HUVECs	Pro-angiogenesis	[141]
miR-21	VEGF overexpression	HUVECs	Pro-angiogenesis	[142]
miR-27a	MiR-27a-loaded Exos from RCCC promote tumorigenesis and suppress SFRP1 transcription	HUVECs	Pro-angiogenesis	[143]
miR-92a-3p	KLF2 is the target of exosomal-released miR-92a-3p, which controls morphogenesis	HUVECs	Pro-angiogenesis	[144]
miR-122	a reduction in PKM	Normal cells in the pre-metastatic niche	Promotes metastasis, before angiogenesis	[145]
miR-210	VEGF overexpression	Endothelial cells	Pro-angiogenesis	[146]
miR-1290	SMEK1 is targeted by miR-1290 to produce an angiogenesis phenotype	HUVECs	Pro-angiogenesis	[147]
miR-549a	Exosomal miR-549a inhibits HIF1 in HUVECs, which has an impact on the vasculature and endothelial mobility	HUVECs	Pro-angiogenesis	[148]
miR-21	enhancing M2 polarity signal transcription in TAMs	CD14 + human monocytes	Pro-angiogenesis	[31]
M-phase-related transcripts	Stimulation of cellular proliferation and modification of the M-phase of the cell growth	Endothelial cells	Initiate angiogenesis	[36]
miR-23a	By attacking prolyl, exosomal miR-23a promoted vasculature and dilation of blood vessels. adhesion molecules protein ZO-1 and hydroxylase	HUVECs	Pro-angiogenesis	[149]
miR-181a	Exos released by the hypoxic PTC carried miR-181a, which inhibits DACT2 by decreasing the expression MLL3 and causes YAP-VEGF-mediated vasculature	HUVECs	Pro-angiogenesis	[150]
miR-221-3p	Exos produced from CC cells that contained miR-221-3p increased MVEC vasculature in CC via lowering MAPK10	MVECs	Pro-angiogenesis	[31]
miR-210	Diminishment of EFNA3	Endothelial cells	Pro-angiogenesis	[151]
miR-130a	reduction of c-MYB	HUVECs	Pro-angiogenesis	[36]
miR-21	Rho decreased the expression	HUVECs	Anti-angiogenesis	[152]
miR-141-3p	NF-B and JAK/STAT3 communication mechanisms activation	HUVECs	Pro-angiogenesis	[153]
Neuraminidase	Overexpression of MMP-9 and CXCR4	786–0	Enhance migration and invasion	[154]
Neuraminidase	Src route	HUVECs	Pro-angiogenesis	[155]
Neuraminidase	VEGF production is upregulated, whereas hepaCAM transcription is downregulated	HUVECs	Pro-angiogenesis	[31]
PTCH 1, SMO, SHH, Ihh	Exos from CC cells stimulate pro-angiogenic responses in endothelium by upregulating Hh-GLI signaling and modifying target genes for angiogenesis upstream side	HUVECs	Pro-angiogenesis	[156]
Profilin 2	In H446 and ECs, t PFN2 stimulated Smad2/3 and pERK	HUVECs	Pro-angiogenesis	[31]
PFKFB-3	The development of lactose and Fru-2,6-P2 is rising	HUVECs	Pro-angiogenesis	[157]
RAMP2-AS1 lncRNA	By depressing miR-2355-target 5p's VEGFR2 by miR-2355-5p syphoning, angiogenesis cell membrane receptors are increased	HUVECs	Pro-angiogenesis	[31]
TIE2	Exo-mediated induction of TIE2-expressing macrophages by TIE2-high cancer cells occurs	HUVECs	Pro-angiogenesis	[158]
TGF-β	Transmission reliant on SMAD	Fibroblasts	Pro-angiogenesis and pro-tumorigenesis	[159]
Tetraspanin Tspan8 (D6.1A)	MMP, VEGF, and VEGFR transcription is increased	Endothelial cells	Pro-angiogenesis	[160]
VEGF	uses its tyrosine kinase domains to effect action	HUVECs	Pro-angiogenesis	[31]
VEGF-A	The increased angiogenic capacity of brain ECs	Brain microvascular Endothelial cells	Pro-angiogenesis	[22]
Vasorin	encourage cell migration and expansion	HUVECs	Pro-angiogenesis	[161]
Wnt4	β-catenin/ Wnt circuit	Endothelial cells	Pro-angiogenesis	[22]

Back to article page

ISSN: 1478-811X

Contact us

General enquiries: journalsubmissions@springernature.com