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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer

Fig. 5

NAT derived clones drive myofibroblast activation. A Immunofluorescence micrographs of sections of xenografts formed four weeks after transplantation of clones. Green, E-cadherin; red, Vimentin. Scale bar, 50 Î¼m. B Quantification of fibroblast submucosal accumulation in xenografts based on general scale. Data represented as mean ± SD (Student’s t-test). n = 3 technical replicates. ∗ p < 0.05. C Heatmaps of fibrosis related genes among RNA-seq DEGs (FDR < 0.05) of NAT and HLT. D Gene set enrichment analysis (GSEA) showing the significantly enriched extracellular matrix component pathway (p = 2.06E-4) and EMT pathway (p = 0.0015) in NAT-derived clones

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Cell Communication and Signaling

ISSN: 1478-811X