Table 7 Intratumoural microbiota that can affect chemotherapy response and toxicity
From: Intratumoural microbiota: from theory to clinical application
Intratumoural microbiota | Mechanism | Cancer | References |
|---|---|---|---|
Lactobacillus | ABX can partially impair the function of cisplatin by upregulating the expression of VEGFA and downregulating the expression of BAX and CDKN1B | Lung cancer | [118] |
Lactobacillus | Participating in some cellular protective processes and preventing cytokine induced epithelial cell damage | Colorectal cancer | [117] |
Gamma Proteobacteria | By expressing the bacterial enzyme cytidine deaminase (CDD), chemotherapeutic drug gemcitabine is metabolized into its inactive form | Pancreatic ductal adenocarcinoma (PDA) | [21] |