From: Intratumoural microbiota: from theory to clinical application
Intratumoural microbiota | Mechanism | Cancer | References |
---|---|---|---|
E.coli Nissle 1917 (EcN) | Inducing apoptosis in tumor cells by inhibiting AKT1 and Bcl-xL while activating PTEN and Bax | Colorectal cancer | [74] |
Pediococcus pentosaceus | Inducing apoptosis in tumor cells by generating conjugated linoleic acid | Prostate Cancer | [75] |
Clostridium Butyricum MIYAIRI 588 (CBM 588) | Inducing apoptosis in tumor cells through the TLR2/4 signaling pathway | Bladder cancer | [76] |
Neisseria Meningitidis | Inducing apoptosis by generating Azurin-like protein LAZ | Brain cancer | [77] |
Salmonella | Inducing hypoxic conditions | Melanoma | |
Salmonella | Inducing autophagy through downregulation of the AKT/mTOR pathway | Melanoma | [80] |
C. novyi-NT | Secreting various exotoxins | Colorectal cancer Leiomyosarcoma Liver Cancer | [81] |
Listeria Monocytogenes | 1. Producing high ROS levels 2. Enhancing CD8-T and NK cell responses by increasing IL-12 | Colorectal cancer | [82] |