Table 11 Intratumoural microbiota that can be programmed and modified
From: Intratumoural microbiota: from theory to clinical application
Intratumoural microbiota | Mechanism | Cancer | References |
|---|---|---|---|
E. coli | Genetically engineered E.coli increases L-arginine concentration and enhances T cell infiltration in the tumor microenvironment | Colorectal cancer | [137] |
Salmonella | Salmonella strains were genetically modified to enable the expression of Fas ligand (FasL), which can effectively deliver the toxic but anti-tumor cytokine to the tumor site, thus enhancing the therapeutic efficacy of the treatment | Colorectal cancer Breast cancer | [136] |