Fig. 1

Mice deficient of Axl or Mertk have a significant increase in antibody-induced arthritis, but Tyro3 deificent mice have an opposite phenotype. Axl^−/− mice, Mertk^−/− mice or Tyro3^−/− mice and their littermate WT controls received intraperitoneal injection of 150 μL of K/BxN serum twice on d 0 and d 2. Joint diameter (A) and clinical scores (B) was evaluated every day, and the changes from that measured on d 0 were recorded. The hind paws of Axl^−/− mice (C), Mertk^−/− mice (D), Tyro3^−/− mice (E) and their littermate WT controls were photographed on day 0 and day 8 after K/BxN serum injection. Data are means ± SEM, n = 8. Joint diameters were abalyzed using Unpaired t test with Welch's correction (A). Clinical scores were anaylzyed by Mann Whitney U test (B). *, P < 0.05; **, P < 0.01