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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2

Fig. 6

Depletion of the THBS2 gene reduces the tumor-promoting ability of BMSC-MVs in nude mouse xenografts. A-C Representative images of tumor, tumor size and tumor weight in nude mice 3 weeks after subcutaneous injection of MGC-803 cells alone, MGC-803 cells cocultured with sh-NC-MVs, MGC-803 cells cocultured with Hp + sh-NC-MVs, MGC-803 cells cocultured with sh-THBS2-MVs, and MGC-803 cells cocultured with Hp + sh-THBS2-MVs. D, E Representative PHH3 IHC images and quantitative analysis of the PHH3 index of tumor sections from different groups of nude mice are shown. F Representative PET-CT images of nude mice 3 months after subcutaneous injection with MGC-803 cells alone, MGC-803 cells cocultured with sh-NC-MVs, MGC-803 cells cocultured with Hp + sh-NC-MVs, MGC-803 cells cocultured with sh-THBS2-MVs, and MGC-803 cells cocultured with Hp + sh-THBS2-MVs. The white arrow indicates suspected abdominal metastasis of xenograft tumors. BMSCs: bone marrow-derived mesenchymal stem cells; MVs: microvesicles; Hp: Helicobacter pylori; GC: gastric cancer; IHC: immunohistochemistry. **P < .01, ***P < .001, ****P < .0001, NS: no significance

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Cell Communication and Signaling

ISSN: 1478-811X