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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2

Fig. 3

MVs derived from BMSCs with H. pylori intervention promote the metastasis of GC in nude mice xenografts in vivo. A Representative PET-CT images of nude mice 4 weeks after intraperitoneal injection with MGC-803 cells alone, MGC-803 cells cocultured with BMSC-MVs, and MGC-803 cells cocultured with Hp + BMSC-MVs. The white arrow indicates suspected abdominal metastasis of xenograft tumors. B The SUVmax values of intraperitoneal metastases in different groups of nude mice. C, D Representative images and tumor weights of intraperitoneal metastatic tumors in different groups of nude mice. E Representative CT images of nude mice 4 weeks after tail vein injection with MGC-803 cells alone, MGC-803 cells cocultured with BMSC-MVs, and MGC-803 cells cocultured with Hp + BMSC-MVs. F H&E pathological images of lung tissue 4 weeks after tail vein injection in different groups of nude mice. BMSCs: bone marrow-derived mesenchymal stem cells; MVs: microvesicles; Hp: Helicobacter pylori; GC: gastric cancer; ***P < .001, NS: no significance

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Cell Communication and Signaling

ISSN: 1478-811X