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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2

Fig. 2

MVs derived from BMSCs with H. pylori intervention enhance the proliferation, migration and invasion of MGC-803 cells in vitro and promote the development of GC in nude mouse xenografts. A-C The proliferation of MGC-803 cells with or without BMSC-MV/Hp + BMSC-MV intervention. D The migration of MGC-803 cells with or without BMSC-MV/Hp + BMSC-MV intervention. E The invasion of MGC-803 cells with or without BMSC-MV/Hp + BMSC-MV intervention. F–H. Representative images of tumor, tumor size and tumor weight in nude mice 3 weeks after injection of MGC-803 cells alone, MGC-803 cells cocultured with BMSC-MVs, and MGC-803 cells cocultured with Hp + BMSC-MVs. I Representative PHH3 IHC images and quantitative analysis of the PHH3 index of tumor sections from MGC-803 cells alone, MGC-803 cells cocultured with BMSC-MVs, and MGC-803 cells cocultured with Hp + BMSC-MVs are shown. BMSCs: bone marrow-derived mesenchymal stem cells; MVs: microvesicles; Hp: Helicobacter pylori; GC: gastric cancer; IHC: immunohistochemistry. *P < .05, **P < .01, ***P < .001

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Cell Communication and Signaling

ISSN: 1478-811X