Table 2 The role of CAFs labeled by cancer-restraining markers in various kinds of cancer
From: What is new in cancer-associated fibroblast biomarkers?
Bio marker | Main origin | Description | Roles in cancers | |||
|---|---|---|---|---|---|---|
Pancreatic cancer | Breast cancer | Colorectal cancer | Lung cancer | |||
Meflin | Not clear | Glycosylated phosphatidylinositol anchored protein | Attenuating tumor aggressiveness; positively correlated with higher differentiated pathological histological features and better prognosis | - | - | Sensitive to ICB treatment |
CD146 | Vascular endothelial cells | Cell adhesion molecule | Related to low histological grade and high-grade pancreatic intraepithelial neoplasia; inhibiting invasion and migration of cancer cells; better prognosis marker | Maintaining ER expression, estrogen-dependent proliferation and sensitivity to tamoxifen | - | - |