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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: TGF-β1 upregulates secreted protein acidic and rich in cysteine expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome

Fig. 5

SPARC is upregulated in the ovaries of OHSS rats. A Representative rat ovaries were photographed from control (Ctrl) and OHSS groups (left panel). Ovarian weight and body weight were measured in both Ctrl (n = 5) and OHSS (n = 5) groups after OHSS induction. B-E The mRNA levels of Vegf (B), Tgfb1 and Cyp19a1 (C), Sparc (D), and Slug (E) in ovaries of Ctrl and OHSS rats were examined by RT-qPCR. F Pearson’s correlation analysis was performed to evaluate the correlation between Tgfb1 and Sparc mRNA levels in Ctrl and OHSS rats. G Representative images of immunostaining for SPARC in rat ovarian sections. Original magnification: 20 × and 200x. The scale bar represents 500 μm and 50 μm. H Quantification results for SPARC in Ctrl and OHSS rat ovaries. I SPARC protein levels in the rat serum were examined by ELISA. The results are expressed as the mean ± SD

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Cell Communication and Signaling

ISSN: 1478-811X