Table 1 Alterations in stem cell characteristics with age [54]
From: A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity
Stem cells | Self-renewal in senescence tissuesa | Proliferative activity | Differentiation capability | Regeneration and repair |
|---|---|---|---|---|
HSCs | About × 2–6 | diminished | Increased myeloid cell production | Immune suppression, reduced engraftment potential |
NSCs | About ÷ 2 | diminished | Maintained in vitro | - |
MuSCs | About ÷ 2 | diminished | Increased fibrosis after injury | Myofibril regeneration and reduced engraftment potential |
ISCs |  =  | diminished | Increased secretory lineage cells | UV exposure reduces generation; response delayed |
HFSCs |  =  | diminished |  =  | The hair cycle stops, and wounds take longer to heal |