Fig. 3
From: A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity
The schematic comparison of aged and young HSCs function in BM. While the total number of cells with regenerative potential in the BM of elderly adults increases, the extent to which specific old cells can still chip away at blood cell production becomes highly variable. Young HSCs are home to the BM and centralize near endosteum. They have great self-renewal and regenerative potential and a moderate differentiation ability towards lymphoid and myeloid progenitor cells. The location of elderly HSCs in the BM is distinguished from that of young HSCs; elderly HSCs centralize away from the endosteal stem cell niche following their transplantation