Fig. 2
From: A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity
Maturated bone marrow (BM) stem cell niche. In the osteoblast niche (by using Notch, Wnt, and PGE-2 pathways), HSCs exist near the osteoblast, which is regulated by bone morphogenetic protein (BMP). In addition, HSCs are as well as exist near the blood vessels in the vascular niche. The stromal cell-derived factor 1 (SDF1), as well as recognized as C-X-C motif chemokine 12 (CXCL12), controlled the immigration of HSCs in the blood flow to the BM. In vivo, the osteoblast and vascular niches may be close to one another. The BM environment also includes stromal cells, which protect hematopoiesis, such as the generation of cytokines, including c-Kit ligand, which was induced by stem cells and progenitors