Fig. 3

Mechanisms of lncRNAs function. A Some lncRNAs have short ORF regions. B LncRNAs can prevent mRNA degradation by recruiting specific proteins. C LncRNAs binding proteins to prevent or attenuate their binding to mRNAs. D LncRNAs binding to a primary RNA transcript and change the splicing pattern. E LncRNAs recruiting the mediator complex to an enhancer region for promote loop formation and transcription of target genes. F LncRNAs transcripts evicting proteins from chromatin to maintain a DNA-free methylation site for mRNA transcription. G LncRNAs can recruit specific proteins to target sites in the genome. H Some LncRNAs transcribed from an enhancer region can inhibit gene transcription process by interfering with enhancer contacting with promoter. I LncRNAs act as “scaffoldings” in the process of forming protein complexes