Fig. 2
From: Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
Summarized scheme regarding the inhibitory effect of phenolic compounds on Nrf2. Nrf2 inhibition by phenolic compounds leads to increasing the sensitivity of cancer cells to conventional anticancer therapy, reducing tumor growth and cancer cells death. [105] Abbreviations and symbols: ↑ increase, ↓ decrease, Nrf2 (nuclear transcription factor), ROS (Reactive oxygen species), Nrf2-Keap 1 (Kelch-like ECH-associated protein 1), Ub (Ubiquinone), NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells, Cox-2 (Cyclooxygenase-2), NQO1 (NAD(P)H quinone oxidoreductase 1), (GPx) Glutathione peroxidase, JNK Jun N-terminal kinases, ICAM-1 (Intercellular Adhesion Molecule 1)