Table 6 Studies of clinical samples investigate the effect of miRNA-93 in diseases that are not malignant
From: MiRNA-93: a novel signature in human disorders and drug resistance
Disease type | miRNA type | Number of clinical samples | Targets/pathways | Expression | Function | Ref |
|---|---|---|---|---|---|---|
Polycystic ovary syndrome | miRNA-93 | 25- PCOS and biochemical hyperandrogenemia | - | Upregulated | MiRNA-93 levels were higher in the blood of PCOS patients who had higher insulin and testosterone levels | [112] |
miRNA-93 | 41 subjects (20 control and 21 PCOS) | GLUT4 | Upregulated | In PCOS-associated adipose tissue (AT), overexpression of miRNA-93 decreases GLUT4 expression | [111] | |
Postmenopausal osteoporosis | miRNA-93-5p | Patients with PMOP (n = 30) and controls (n = 30) | CircRNA_0048211/ miRNA-93- 5p/BMP2 | Downregulated (by circRNA_0048211) | MiRNA-93-5p is negatively targeted by CircRNA 004,211, which increases BMP2 and slows the course of PMOP | [109] |
Peripheral arterial disease | miRNA-93 | 146 sample with PAD (79 male and 67 female) | CDKN1A | Upregulated | MiRNA-93 increases angiogenesis by increasing EA. hy926 endothelial cell proliferation, migration, and tube formation, which decreases CDKN1A expression | [110] |
Mild Head Trauma | miRNA 93 | 59 sample and 91 controls | - | Upregulated | Validity of Serum miRNA 93 Can Reduce the Need for CT scans in Patients with Mild Head Injury | [113] |
Multiple blunt trauma | miRNA-93 | A total of 60 healthy controls and 50 consecutive persons with MBT who are matched for age and sex | - | Upregulated | In individuals with multiple traumas, miRNA-93 may be a helpful biomarker for assessing the severity of the injuries | [114] |
Periodontitis | miRNA-93 | 3 sample | HIF-1α, NFAT5 | Upregulated | MiRNA-93 expression increased in periodontitis patients, whereas NFAT5 mRNA expression decreased. Additionally, hypoxic environments cause GMSCs to increase HIF-1 expression | [115] |
Chronic kidney disease | miRNA-93-5p | 67 CKD patients with KT, 73 patients with CKD stages 3 to 5, and 36 healthy controls | - | Downregulated | Levels of miRNA-93-5p are linked to CKD stage, inflammation, and bone metrics | [116] |
Rheumatoid arthritis | miRNA-93-5p | 49 RA sample and 38 controls | MMP-3, IL-16 | Upregulated | MMP-3 promoter methylation and miRNA-93-5p expression levels may serve as helpful biomarkers for the pathophysiology of RA | [22] |