Table 4 Based on the results of cell line investigations, it can be seen how miRNA-93 contributes to the pathogenesis of diseases
From: MiRNA-93: a novel signature in human disorders and drug resistance
Disease type | miRNA type | Interactions | Cell lines | Associated phenotype with dysregulation of miRNA-93 | Ref |
|---|---|---|---|---|---|
Acute myocardial infraction | miRNA-93-5p | TLR4/NF-κB-Mediated Inflammatory Response | H9c2 | ↑miRNA-93-5p, ↓Atg7-mediated autophagy and TLR4-mediated inflammatory: ↓myocardial injury | [105] |
Acute kidney injury | miRNA-93 | IRAK4/NF-κB and IL-6R/STAT3 | HK-2 | ↑SNHG14, ↓ miRNA-93, ↑IRAK4/NF-κB and IL-6R/STAT3 signaling: ↑Sepsis-Induced Acute Kidney Injury | [104] |
Atherosclerosis | miRNA-93 | ABCA1 | THP1 | ↑miRNA-93, ↓ ABCA1: ↑ disease progression |  |