From: MiRNA-93: a novel signature in human disorders and drug resistance
Tumor/ disorder type | Samples | miRNA-93 expression (Tumor vs. Normal) | Cox regression and Kaplan–Meier analysis | Association of miRNA-93 expression with clinicopathologic characteristics | Ref |
---|---|---|---|---|---|
Breast carcinoma | 20 BC patient tissue | miRNA-93 (Up) | - | Lymph node metastasis | [49] |
Colon cancer | 138 pairs of CC sample | miRNA-93 (Down) | Downregulation is associated with poor survival in patients | Positive nodal metastasis (P = 0.006), positive distant metastases (P = 0.01), and advanced tumor stage (P = 0.02) | [100] |
Uterine cancer | 176 UC sample + 100 healthy controls | miRNA-93 (Up) | The prognosis of UC patients is correlated with upregulation | Lymph node metastases and pathological stage | [8] |
Laryngeal squamous cell carcinoma | 59 pairs of LSCC samples | miRNA‐93‐5p (Up) | - | Histological grade, lymph node metastasis | [97] |
Colorectal cancer | -First cohort: (35 non-early relapse CRC patients + 42 early relapse CRC patients) -Second cohort 45 CRC patients | miRNA-93 (Up) | An early UICC stage of CRC is linked to upregulation | G2 phase cell cycle arrest | [39] |
Endometrial carcinoma | 50 paired of EC tissues | miRNA‐93‐5p (Up) | Upregulation is associated with patients' low survival rates from EC | The EC's FIGO stage and lymph node metastases | [94] |
Lacrimal gland adenoid cystic carcinoma | 5 ACC patient tissues + 3 healthy controls | miRNA‐93‐5p (Up | - | Tumor migration, invasion, and proliferation | [101] |
Ovarian cancer | - | miRNA-93-5p (Down) | Downregulation is linked to a poor prediction of patient survival time | Weakly increase OC cell apoptosis and inhibit cell migration | [98] |
Esophageal cancer | 30 ESCA samples + 30 healthy controls | miRNA-93 (Up) | - | - | [102] |
Squamous cell carcinoma of the head and neck | 522 SCCHN samples + 44 healthy controls | miRNA‐93‐5p (Up) | Upregulation in SCCHN is associated with a poor prognosis | Metastasis of lymph nodes | [99] |
Renal cell carcinoma | 138 paired ccRCC sample | miRNA-93-3p (Up) | Upregulation is correlated with poor prognosis | - | [93] |
Endometrial cancer | 100 EC patient | miRNA-93 (Up) | Upregulation is associated with Poor overall median survival | Lymph node involvement | [103] |
Retinoblastoma | 23 human RB + 12 normal retinae | miRNA-93-5p (Up) | - | - | [95] |
Osteosarcoma | - | miRNA-93-3p (Downregulated (by LncRNA AWPPH)) | Downregulation is associated with OS poor prognosis | TNM stage, metastasis | [96] |