Table 2 Impact of miRNA-93 in carcinogenesis based on research in animal models
From: MiRNA-93: a novel signature in human disorders and drug resistance
Type of tumor | Types of miRNAs | Animal model | Methods of Manipulation and Cellular Grafting | Phenotypes linked to miRNA-93 dysregulation | Ref |
|---|---|---|---|---|---|
NSCLC | miRNA-93 | Nude mice | Injecting miR-93- or control-transfected H1993 cells subcutaneously | ↑miRNA-93 (which targets DAB2): ↓tumor growth | [45] |
Esophageal carcinoma | miRNA-93 | Nude mice | Injections of transfected SKGT4 cells (circ-21–93 or circ-scr) under the skin | ↑miRNA-93: ↓xenografted tumor growth | [92] |
Hepatocellular carcinoma | miRNA-93-5p | BALB/c nude mice | Subcutaneous injection of lentiviral overexpression of miR-93-5p in SK-Hep-1 cells + lentiviral antagonist of miR-93-5p in MHCC-97H cells | ↑miRNA-93-5p (directly targets MAP3K2): ↑ cell proliferation | [59] |
Mammary tumor | miRNA-93 | ACI rats | Injecting 3 mg of E2 pellets into MCF-10A and T47D cells infected with a lentiviral vector subcutaneously | ↑miRNA-93(targets NRF2): ↑Clonability, development of mamospheres, and migratory characteristics of MCF-10A cells, and ↓ apoptosis | [90] |
Epithelial ovarian carcinoma | miRNA-93-5p | BALB/c nude mice | Injections of miR-93-5P or mock-transfected OVCAR3 cells under the skin | ↓miRNA-93-5p (directly targets RhoC): ↓ proliferation, ↑G1 or S arrest and apoptosis | [91] |
Renal carcinoma | miRNA-93-3p | BALB/c nude mice | Transfected 786-O cells were injected subcutaneously with either a control lentivirus or an anti-miR-93-3p lentivirus | ↑miRNA-93-3p (directly targets PEDF): ↑cell tumorigenesis and metastasis | [93] |