Table 1 Phenotypic marker of mouse and human monocyte and macrophage subsets as per references [15,16,17,18,19,20,21,22,23,24,25]
From: Crosstalk between macrophages and cardiac cells after myocardial infarction
Markers | Type | Location | Species | Monocyte | RTM | M1 | M2 |
|---|---|---|---|---|---|---|---|
CD45 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
CD11b | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
CD11c | Receptor | Cell membranes | Human/Mouse | ＋/- | -/- | ＋/- | -/- |
CD68 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
CD80 | Receptor | Cell membranes | Human/Mouse | -/- | low/low | ＋/＋ | ＋/＋ |
CD86 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | -/- | ＋/＋ | ＋/＋ |
CD206 | Receptor、 Lectin | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | -/- | ＋/＋ |
iNOS | Enzyme | Cytoplasm | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
Arg1 | Enzyme | Cytoplasm | Human/Mouse | -/- | ＋/＋ | -/- | ＋/＋ |
CCR2 | Receptor | Cell membranes | Human/Mouse | ±/± | -/- | high/＋ | low/± |
CX3CR1 | Receptor | Cell membranes | Human/Mouse | -/± | -/- | low/± | high/＋ |
IL-6 | Cytokine | Secreted | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
IL-10 | Cytokine | Secreted | Human/Mouse | -/- | ＋/＋ | -/- | ＋/＋ |
TNF-α | Cytokine | Secreted | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
CD14 | Receptor | Cell membranes | Human | ＋ | ＋ | high | ＋ |
CD16 | Receptor | Cell membranes、Secreted | Human | ± | ＋ | - | high |
HLA-DR | Multi-subunit complex、Receptor | Cell membranes | Human | ＋ | ＋ | ＋ | ＋ |
F4/80 | Receptor | Cell membranes | Mouse | ＋ | ＋ | ＋ | ＋ |
Ly-6C | Receptor | Cell membranes | Mouse | high/low | low | high | low |
MHC-II | Multi-subunit complex、Receptor | Cell membranes | Mouse | ＋ | ＋ | ＋ | ＋ |
Fizz1 | Other | Secreted | Mouse | - | - | - | ＋ |
Ym1 | Lectin | Nucleus、Secreted | Mouse | - | - | - | ＋ |