Fig. 1
From: Crosstalk between macrophages and cardiac cells after myocardial infarction
Crosstalk between macrophages and cardiomyocytes (CMs). A Dead CMs induce shedding of the MERTK receptor. B Macrophages phagocytose exophers to maintain homeostasis. C Macrophages secrete OSM to promote CM proliferation through gp130/Src/Yap-Notch and Yap-ctgf/Areg pathways. D The dsDNA from CMs that have undergone cell death stimulates the cGAS-STING-IRF3 pathway to induce the apoptosis of healthy CMs. E Macrophages interact with CMs via focal adhesion complex markers (such as β-integrin) and activate TRPV4 to promote the expression of M-CSF by sensing left ventricular pressure. F CD47 expression on CMs impairs the efferocytosis by macrophages