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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment

Fig. 3

Different approaches for treating hematologic neoplasms through exosomes. Blood is drawn from the patient and exosomes will be isolated and then modified. Modified exosomes with specific miRNA and oligonucleotides cargos either obtained from patient or synthesized could be locally injected or systemically delivered. These cargos could 1) Inhibit oncomiRNAs in cancer cells by complementary oligonucleotide attachment, 2) Induce robust T cell response against tumors via dendritic cells (DCs) filled with modified exosomes, and 3) Suppress tumor growth by knocking out the target oncogene

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Cell Communication and Signaling

ISSN: 1478-811X