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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy

Fig. 9

TFEB knockdown reduced ALP function, aggravated AD-like pathology and cell apoptosis of HG-cultured HT22 cells. TFEB, LC3, p62, CTSB and LAMP1 and were measured via western blotting in HT22 cells (A), GAPDH was used as the loading control, n = 3. Results of CTSB activity of the HT22 cells, the activity of CTSB was expressed as fluorescent units/ug protein (B), n = 3. APP, Aβ42, p-Tau and Tau were measured via western blotting in HT22 cells (C), GAPDH was used as the loading control, n = 3. HT22 cell apoptosis was assayed by flow cytometry, data are presented as the mean ± standard deviation (D), n = 3. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X