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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy

Fig. 2

HG increased cell apoptosis and AD-like pathology in HT22 cells, which was related to the dynamic change of ALP function. HT22 cell apoptosis was assayed by flow cytometry, data are presented as the mean ± standard deviation (A), n = 3. APP, Aβ42, p-Tau and Tau were measured via western blotting in HT22 cells (B); LC3, p62, CTSB and LAMP1 were measured via western blotting in HT22 cells (C); GAPDH was used as the loading control, n = 3. Results of CTSB activity of the HT22 cells, the CTSB activity was expressed as fluorescent units/ug protein (D), n = 3; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X